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Keep an eye on Carefully (1)pentobarbital will minimize the extent or outcome of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to the lessen in fentanyl plasma concentrations, not enough efficacy or, possibly, growt